[Frontiers in Bioscience 8, a102-109, May 1, 2003] 102 DELIVERY OF TRANSFERRIN AND IMMUNOGLOBULINS TO THE VENTRICULAR SYSTEM OF THE RAT

نویسنده

  • Torben Moos
چکیده

1. Abstract 2. Introduction 3. Materials and Methods 3.1. Animals 3.2. Experimental procedures 3.3. Immunohistochemistry 4. Results 4.1. Adult rat 4.1.1. Transferrin receptor 4.1.2. Transferrin 4.1.3. OX26 4.1.4. Non-immune IgG 4.2. P7 rat 4.2.1. Transferrin receptor 4.2.2. Transferrin 4.2.3. OX26 4.2.4. Non-immune IgG 5. Discussion 5.1. Circulation of transferrin and OX26 in the brain 5.2. Cellular uptake of transferrin and OX26 5.3. Is the cerebral ventricle a suitable site for injecting macromolecules 6. Acknowledgments 7. References

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes.

An ideal therapeutic for cancer would be one that selectively targets to tumor cells, is nontoxic to normal cells, and that could be systemically delivered, thereby reaching metastases as well as primary tumor. Immunoliposomes directed by monoclonal antibody or its fragments are promising vehicles for tumor-targeted drug delivery. However, there is currently very limited data on gene delivery u...

متن کامل

Standardization for four protein analytes with the Behring Nephelometer.

Owing to the generally higher values observed in the initial establishment of immunoglobulins (Ig) G, A, and M assays with the Behring Nephelometer, we elected to verify five commercial protein calibrators. This initial verification was performed by standardizing the Behring Nephelometer with the World Health Organization (WHO) International Reference Preparation for Human Serum Immunoglobulins...

متن کامل

Immunologic aspects of leprosy with reference to extravascular immunoglobulins: their excretion profile in urine.

An aliquot of 24-hour urine collected from leprosy patients was concentrated and examined for the presence of albumin, transferrin, IgG, IgA, IgM, IgD, D3, kappa and lambda light chains by the gel diffusion technic using respective monospecific antisera. Urinary protein excretion profile in lepromatous leprosy patients showed that while excretion of transferrin in the urine was negligible; that...

متن کامل

Nonenzymatic glycation of immunoglobulins does not impair antigen-antibody binding.

We glycated immunoglobulins from commercial kits designed to measure human ferritin, thyrotropin, and transferrin, and compared the calibration curves for assays utilizing glycated antibodies with those of assays utilizing non-glycated antibodies. Glycation was verified by borate affinity chromatography and assay with thiobarbituric acid reagent. We found no evidence that antigen-antibody bindi...

متن کامل

Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis

Autoimmune hepatitis (AIH) is a chronic hepatitis with an increasing incidence. The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. An abnormal iron homeostasis or hyperferritinemia is associated with worse outcome in other chronic liver diseases and after liver transplantation. We assessed the capacity of base...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003